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Jeste li znali da je Avon prva kompanija koja je počela koristiti stabilan retinol u svojim kozmetičkim proizvodima? U Avon laboratorijima u Suffernu, The big apple znanstvenici su sada došli i do još većeg otkrića – Protinola – koji paralelno potiče proizvodnju 2 tipa kolagena i tako dodatno učvršćuje i obnavlja kožu lica. 

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Two factors genuinely stunned us when we started screening Protinol™: the outcomes on sagging, firming and wrinkles were like absolutely nothing we’d at any time noticed before – so fantastic the truth is we experienced to acquire them independently confirmed to make certain we could believe what we have been looking at.

Summary in English, French Goal: Facial skin undergoes main structural and practical adjustments because of intrinsic and extrinsic elements. The objective of the present get the job done is usually to exhibit L-four-thiazolylalaine (L4, Protinol), a non-proteinogenic amino acid demonstrated to stimulate the manufacture of dermal proteins by fibroblasts, is another efficacious topical ingredient for obvious signs of ageing. Procedures: In vitro reports utilizing 3D human skin tissue products have been executed to show alterations in protein and gene expression of important dermal markers in samples dealt with with 0.three% L4 when compared with car Management. In vivo analysis of skin turnover was measured in volunteers soon after treatment with L4 when compared with retinol. Skin biopsies (n = 30) have been taken to research epidermal and dermal improvements in cases treated with L4 and when compared with retinol. Eventually, a clinical evaluation (n = 28) was performed to evaluate the efficacy of L4 around a base formulation employing a variety of ageing parameters inside a inhabitants of ladies 46-66 many years aged with gentle-to-average wrinkles. Success: In vitro experiments on 3D tissues shown substantial changes from the dermal matrix by way of a rise in HA and Professional-collagen I manufacturing in addition to a lower in the expression of inflammatory genes. In vivo biopsy scientific tests shown that L4 and retinol independently elevated epidermal thickness and collagen remodelling noticeably a lot more when compared with The bottom components. Clinical analysis confirmed firmer and smoother skin at day 28 article-therapy with L4 in excess of the auto Manage with no causing Unintended effects such as redness or discomfort. Conclusion: L4 is actually a novel, multi-practical component which offers a superior alternate to available technologies for improving epidermal and dermal parameters website that modify for the duration of ageing and photodamage. Objectif: La peau du visage est sujet à des changements majeurs structuraux et fonctionnels dus à des facteurs intrinsèques et extrinsèques. Dans cette étude, nous montrons que l'acide aminé non-protéinogène L-four-thiazolylalanine (L4, Protinol) est une option intéressante pour une software topique.

Following cleansing and utilizing the eye cream, massage 1 pump of your serum throughout your face and neck till it’s absolutely absorbed. Do this each and every early morning and evening.

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Meet up with Protinol™. Patented Protinol™ is so powerful it's the probable to revolutionise The full marketplace. I'm able to actually say it’s the most fun discovery of my profession, and scientists don’t say such things as that frivolously!

We’re chatting skin sense Together with the lowdown on our exceptional component (that’s right, you gained’t obtain Protinol™ anywhere but Avon), how it differs from retinol and why it’s fast turning into a necessity-have. Ready?

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The enchantment of Protinol™ is its power to convey those two varieties of collagens collectively, indicating you could hope to see results like firmer-experience skin in just seven times* – wow.

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I’ll begin by expressing that I’ve worked in skincare for over twenty years and Avon’s been top how in innovation for decades so I’ve viewed a lot of firsts and new surprise ingredients together the way in which.

 principal forms of collagen which have been critical to the feel and appear of balanced, potent skin. Protinol™ stimulates a rise in the two Collagen I, the most common collagen in skin and collagen III, or ‘toddler’ collagen since it’s affectionately termed.